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Combining the 'bottom-up' and 'top-down' approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

机译：在药代动力学建模中结合“自下而上”和“自上而下”的方法：将pBpK模型与观察到的临床数据相结合

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Tsamandouras, N; Rostami-Hochaghan, Amin; Aarons, Leon;
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年度 2015
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正文语种 eng
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1. Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data [J] . Tsamandouras Nikolaos, Rostami-Hodjegan Amin, Aarons Leon British Journal of Clinical Pharmacology . 2015,第1期

机译：在药代动力学建模中结合“自上而下”和“自上而下”的方法：将PBPK模型拟合到观察到的临床数据
2. Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data [J] . Tsamandouras Nikolaos, Rostami‐Hodjegan Amin, Aarons Leon British journal of clinical pharmacology . 2015,第1期

机译：在药代动力学建模中结合了“自下而上”和“自上而下”的方法：将PBPK模型拟合到观察到的临床数据
3. Poster #047: Comparative Application of Published Top-down and Bottom-up Pharmacokinetic Models of Efavirenz With Respect to Observed Ethiopian Clinical Data [J] . Abiy Habtewold, Andrew Castleman, Joel S. Owen Clinical pharmacology in drug development . 2016,第Suppla1期

机译：海报＃047：Efavirenz的出版自上而下和自下而上的药代动力学模型对观察到的埃塞俄比亚临床资料
4. KINETIC AND MECHANISTIC DATA NEEDS FOR A HUMAN PHSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR ACRYLAMIDE: Pharmacokinetic Model for Acrylamide [C] . Melvin E. Andersen, Joseph Scimeca, Stephen S. Olin, ACS Symposium on Chemistry and Safety of Acrylamide in Food . 2005

机译：用于丙烯酰胺的人体氏药代理（PBPK）模型的动力学和机械数据需求：丙烯酰胺的药代动力学模型
5. An Assessment of the Top-down/Bottom-up Approaches to Policy Analysis and the Impact of State and Local Government Participation on Emergency Management Policy Implementation: Is the Use or Application of a Middle-middle Model or Approach a Better Answer? [D] . Berry, Robert Thomas 2011

机译：对自上而下/自下而上的政策分析方法以及州和地方政府参与对应急管理政策实施的影响的评估：使用或应用中-中模型或方法是否更好？
6. Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data [O] . Nikolaos Tsamandouras, Amin Rostami-Hodjegan, Leon Aarons 2015

机译：在药代动力学建模中结合了自上而下和自上而下的方法：将PBPK模型拟合到观察到的临床数据
7. Combining Top-Down and Bottom-Up Approaches To Energy-Economy Modeling Using Discrete Choice Methods [O] . Nic Rivers, Mark Jaccard 2005

机译：将自上而下和自下而上的方法结合使用离散选择方法进行能源经济建模
8. Approaches for the Application of Physiologically Based Pharmacokinetic (PBPK) Models and Supporting Data in Risk Assessment [R] . 2006

机译：生理学药代动力学（pBpK）模型和支持数据在风险评估中的应用方法

Combining the 'bottom-up' and 'top-down' approaches in pharmacokinetic modelling: Fitting PBPK models to observed clinical data

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